ANGIOTENSIN-CONVERTING ENZYME 2 AND TMPRSS2 EXPRESSIONS IN COVID-19

نویسندگان

چکیده

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters into host cells through the angiotensin-converting enzyme (ACE2) receptor and transmembrane serine protease (TMPRSS2) helps in propagation. Expression of ACE2 gene was found to be higher kidney, testis, heart, thyroid, adipose tissue whereas expression TMPRSS2 highest small intestine, prostate. increases as age increases. Estrogen has a protective role against SARS-CoV-2. Thus mortality rate SARS-CoV-2 is more men compared women. also expressed therefore body mass index disease severity Smoking upregulates lung airway TMPRSS2. Alcoholics have chances get COVID-19 it elevates angiotensin II type 1 receptor. Administer an antioxidant-rich diet fight COVID-19. Patients with hypertension, diabetes, cardiovascular disease, chronic kidney cancer cause increased while administering drugs such ACE inhibitors, I blocker, thiazolidinediones, NSAIDs thus infection. Anti-histo-blood natural antibodies act blood group O. Blacks Histapanic community risk infection white people. Temperature humidity are negatively correlated elevated alveolar population exposed air pollution exposure SARS-CoV In this article, we will compare modifiable non-modifiable factors that affect both first second waves.

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ژورنال

عنوان ژورنال: Innovare journal of medical sciences

سال: 2022

ISSN: ['2321-4406']

DOI: https://doi.org/10.22159/ijms.2022.v10i3.44724